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RtxA1‐Induced Expression of the Small GTPase Rac2 Plays a Key Role in the Pathogenicity ofVibrio vulnificus

17 Nov 2009

Abstract excerpt

Infection with the human pathogen Vibrio vulnificus leads to the generation of reactive oxygen species (ROS) via NAD(P)H oxidase (Nox) in host cells. In the present study, we employed mutant V. vulnificus strains to identify an essential virulence factor responsible for this ROS generation. We found that repeats-in-toxin A1 (RtxA1) expressed by V. vulnificus acts via Nox1 to induce significant ROS generation in...

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PMID: 19919301
DOI: 10.1086/648612

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