Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The value of XPD and XRCC1 genotype polymorphisms to predict clinical outcome in metastatic colorectal carcinoma patients with irinotecan-based regimens.

Journal of cancer research and clinical oncology - 1 Jun 2010

Artac Mehmet, Bozcuk Hakan, Pehlivan Sacide, Akcan Songül, Pehlivan Mustafa, Sever Tugce, Ozdogan Mustafa, Savas Burhan

Abstract excerpt

BACKGROUND: Previous studies have suggested that DNA repair enzyme polymorphisms may bear prognostic value in metastatic colorectal carcinoma (MCRC). METHODS: We prospectively treated 43 MCRC patients with irinotecan-based regimens (XELIRI or IFL). Allelic variants of the XRCC1 gene at codon 399...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Analysis of Variance
Share to Antineoplastic Combined Chemotherapy Protocols

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Camptothecin

Share to Irinotecan

Share to Neoplasm Staging

Share to Survival Analysis

Share to X-ray Repair Cross Complementing Protein 1

Share to Xeroderma Pigmentosum Group D Protein

Source

Identifiers

PMID: 19908066
DOI: 10.1007/s00432-009-0720-3

Genes

XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19908066-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

The value of XPD and XRCC1 genotype polymorphisms to predict clinical outcome in metastatic colorectal carcinoma patients with irinotecan-based regimens.PMID 19908066Read ↗

Determination of ERCC2 Lys751Gln and GSTP1 Ile105Val gene polymorphisms in colorectal cancer patients: relationships with treatment outcome.Semantic proximity Read ↗

Potential role of PIN1 genotypes in predicting benefit from oxaliplatin-based and irinotecan-based treatment in patients with metastatic colorectal cancer.Semantic proximity Read ↗

The combination of ERCC1 and XRCC1 gene polymorphisms better predicts clinical outcome to oxaliplatin-based chemotherapy in metastatic colorectal cancer.Semantic proximity Read ↗

Prediction of response to combination chemotherapy with irinotecan in Greek patients with metastatic colorectal cancer.Semantic proximity Read ↗

Molecular markers of response and toxicity to FOLFOX chemotherapy in metastatic colorectal cancer.Semantic proximity Read ↗

Significant associations of mismatch repair gene polymorphisms with clinical outcome of pancreatic cancer.Semantic proximity Read ↗

Potential application of GSTT1-null genotype in predicting toxicity associated to 5-fluouracil irinotecan and leucovorin regimen in advanced stage colorectal cancer patients.Semantic proximity Read ↗

GSTP1 Ile105Val polymorphism correlates with progression-free survival in MCRC patients treated with or without irinotecan: a study of the Dutch Colorectal Cancer Group.Semantic proximity Read ↗

A polymorphism of the XRCC1 gene predicts for response to platinum based treatment in advanced colorectal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.