Article
Potential application of GSTT1-null genotype in predicting toxicity associated to 5-fluouracil irinotecan and leucovorin regimen in advanced stage colorectal cancer patients.
Oncology reports - 1 Sept 2006
Romero R Zárate, Morales R, Garcia F, Huarriz M, Bandres E, De la Haba J, Gómez A, Aranda E, García-Foncillas J
Abstract excerpt
Our aim was to evaluate the role of C-69T in GSTA1, Ile105Val in GSTP1, null allele in GSTT1 and GSTM1 in the prediction of toxicity in patients treated with 5-Fu/CPT-11/Lv regimens in metastatic CRC patients. Fifty-one patients with CRC metastatic disease were analysed. All patients had bidimens...
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