Defective formation of the inner limiting membrane in laminin beta2- and gamma3-null mice produces retinal dysplasia.

doi:10.1167/iovs.09-4645

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Article

Defective formation of the inner limiting membrane in laminin beta2- and gamma3-null mice produces retinal dysplasia.

Investigative ophthalmology & visual science - 1 Mar 2010

Pinzón-Duarte Germán, Daly Gerard, Li Yong N, Koch Manuel, Brunken William J

Abstract excerpt

PURPOSE: Retinal basement membranes (BMs) serve as attachment sites for retinal pigment epithelial cells on Bruch's membrane and Müller cells (MCs) on the inner limiting membrane (ILM), providing polarity cues to adherent cells. The beta2 and gamma3 chains of laminin are key components of retinal BMs throughout development, suggesting that they play key roles in retinal histogenesis. This study was conducted to...

Topics

Animals
Basement Membrane
Blotting, Western
Cell Differentiation
Dark Adaptation
Electroretinography
Fluorescent Antibody Technique, Indirect
Gene Deletion
Genotype
Immunohistochemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Laminin

Mice

Mice, Knockout

Polymerase Chain Reaction

Retina

Retinal Dysplasia

Source

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Identifiers

PMID: 19907020
DOI: 10.1167/iovs.09-4645
PMCID: PMC2868416

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