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Article

Clinical heterogeneity in monogenic diabetes caused by mutations in the glucokinase gene (GCK-MODY).

Diabetes care - 1 Feb 2010

Cuesta-Muñoz Antonio L, Tuomi Tiinamaija, Cobo-Vuilleumier Nadia, Koskela Hanna, Odili Stella, Stride Amanda, Buettger Carol, Otonkoski Timo, Froguel Philippe, Grimsby Joseph, Garcia-Gimeno Maria, Matschinsky Franz M

Abstract excerpt

OBJECTIVE: To evaluate the heterogeneity in the clinical expression in a family with glucokinase mature-onset diabetes of the young (GCK-MODY). RESEARCH DESIGN AND METHODS: Members (three generations) of the same family presented either with overt neonatal hyperglycemia, marked postprandial hyperglycemia, or glucosuria. Homeostasis model assessment of insulin resistance (HOMA(IR)) and insulinogenic and...

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Identifiers

PMID: 19903754
DOI: 10.2337/dc09-0681
PMCID: PMC2809268

Genes

GCK

Variants

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Clinical heterogeneity in monogenic diabetes caused by mutations in the glucokinase gene (GCK-MODY).PMID 19903754Read ↗

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Genotype-phenotype discrepancy among family members carrying a novel glucokinase mutation: insights into the interplay of GCK-MODY and insulin resistanceSemantic proximity Read ↗

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Genetic and clinical characteristics of Chinese children with Glucokinase-maturity-onset diabetes of the young (GCK-MODY).Semantic proximity Read ↗

Analysis of the GCK gene in 79 MODY type 2 patients: A multicenter Turkish study, mutation profile and description of twenty novel mutations.Semantic proximity Read ↗

[A three-year follow-up observation of a pedigree of maturity onset diabetes of the young caused by a novel mutation of glucokinase and literature review].Semantic proximity Read ↗

Molecular and clinical characterization of glucokinase maturity-onset diabetes of the young (GCK-MODY) in Japanese patients.Semantic proximity Read ↗

GCK gene mutations are a common cause of childhood-onset MODY (maturity-onset diabetes of the young) in Turkey.Semantic proximity Read ↗

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