Article
Little evidence for reversibility of trimethoprim resistance after a drastic reduction in trimethoprim use.
The Journal of antimicrobial chemotherapy - 1 Feb 2010
Sundqvist M, Geli P, Andersson D I, Sjölund-Karlsson M, Runehagen A, Cars H, Abelson-Storby K, Cars O, Kahlmeter G
Abstract excerpt
OBJECTIVES: The worldwide rapid increase in antibiotic-resistant bacteria has made efforts to prolong the lifespan of existing antibiotics very important. Antibiotic resistance often confers a fitness cost in the bacterium. Resistance may thus be reversible if antibiotic use is discontinued or re...
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