Article
Ethambutol-induced optic neuropathy linked to OPA1 mutation and mitochondrial toxicity.
Mitochondrion - 1 Mar 2010
Guillet Virginie, Chevrollier Arnaud, Cassereau Julien, Letournel Franck, Gueguen Naïg, Richard Laurence, Desquiret Valérie, Verny Christophe, Procaccio Vincent, Amati-Bonneau Patrizia, Reynier Pascal, Bonneau Dominique
Abstract excerpt
Ethambutol (EMB), widely used in the treatment of tuberculosis, has been reported to cause Leber's hereditary optic neuropathy in patients carrying mitochondrial DNA mutations. We study the effect of EMB on mitochondrial metabolism in fibroblasts from controls and from a man carrying an OPA1 mutation, in whom the drug induced the development of autosomal dominant optic atrophy (ADOA). EMB produced a mitochondrial...
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