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Article

Prediction of clonogenic cell survival curves based on the number of residual DNA double strand breaks measured by γH2AX staining

1 Nov 2009

Abstract excerpt

PURPOSE: To assess the potential of using the residual phosphorylation of histone H2AX (gammaH2AX) after irradiation as a marker of radiosensitivity in vitro. MATERIAL AND METHODS: Confluent cell cultures of FaDu and SKX human squamous cell carcinoma lines were irradiated with graded single doses. Twenty-four hours after irradiation cells were seeded for standard colony forming assay (CFA). In parallel, staining...

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PMID: 19895280
DOI: 10.3109/09553000903242149

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