Article
Increasing the number of thyroid lesions classes in microarray analysis improves the relevance of diagnostic markers.
PloS one - 29 Oct 2009
Fontaine Jean-Fred, Mirebeau-Prunier Delphine, Raharijaona Mahatsangy, Franc Brigitte, Triau Stephane, Rodien Patrice, Goëau-Brissonniére Olivier, Karayan-Tapon Lucie, Mello Marielle, Houlgatte Rémi, Malthiery Yves, Savagner Frédérique
Abstract excerpt
BACKGROUND: Genetic markers for thyroid cancers identified by microarray analysis have offered limited predictive accuracy so far because of the few classes of thyroid lesions usually taken into account. To improve diagnostic relevance, we have simultaneously analyzed microarray data from six public datasets covering a total of 347 thyroid tissue samples representing 12 histological classes of follicular lesions...
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