Article
Soft X-ray tomography of phenotypic switching and the cellular response to antifungal peptoids in Candida albicans.
Proceedings of the National Academy of Sciences of the United States of America - 17 Nov 2009
Uchida Maho, McDermott Gerry, Wetzler Modi, Le Gros Mark A, Myllys Markko, Knoechel Christian, Barron Annelise E, Larabell Carolyn A
Abstract excerpt
The opportunistic pathogen Candida albicans can undergo phenotypic switching between a benign, unicellular phenotype and an invasive, multicellular form that causes candidiasis. Increasingly, strains of Candida are becoming resistant to antifungal drugs, making the treatment of candidiasis difficult, especially in immunocompromised or critically ill patients. Consequently, there is a pressing need to develop new...
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