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Article

Real-Time Imaging of the Azole Class of Antifungal Drugs in Live Candida Cells.

ACS chemical biology - 21 Jul 2017

Benhamou Raphael I, Bibi Maayan, Steinbuch Kfir B, Engel Hamutal, Levin Maayan, Roichman Yael, Berman Judith, Fridman Micha

Abstract excerpt

Azoles are the most commonly used class of antifungal drugs, yet where they localize within fungal cells and how they are imported remain poorly understood. Azole antifungals target lanosterol 14α-demethylase, a cytochrome P450, encoded by ERG11 in Candida albicans, the most prevalent fungal pathogen. We report the synthesis of fluorescent probes that permit visualization of antifungal azoles within live cells....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28472585
DOI: 10.1021/acschembio.7b00339
PMCID: PMC7030953

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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