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Candida tropicalis morphotypes show altered cellular structure and gene expression pre- and post-exposure to fluconazole.

Medical mycology - 12 Nov 2024

Dos Santos Murilo M, de Souza Cássia M, Furlaneto-Maia Luciana, Furlaneto Marcia C

Abstract excerpt

A feature of Candida tropicalis is its ability to undergo phenotypic switching that can affect antifungal sensitivity and virulence traits. Here, we investigated the effect of switching on alterations at the cellular structure level of C. tropicalis morphotypes and whether exposure to fluconazole (FLC) in vitro could be associated with these alterations in a morphotype-dependent manner. Candida tropicalis...

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PMID: 39504478
DOI: 10.1093/mmy/myae110

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