Article
Azole-resistance in Aspergillus: proposed nomenclature and breakpoints.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy - 1 Dec 2009
Verweij Paul E, Howard Susan J, Melchers Willem J G, Denning David W
Abstract excerpt
Reports of itraconazole resistance in Aspergillus fumigatus have been more frequent since the millennium. Identifying azole resistance is critically method dependent; nevertheless reproducible methods, reflective of in vivo outcome, are now in routine use. Some isolates also have elevated MICs to posaconazole and voriconazole. Multiple mechanisms of resistance are now known to be responsible, with differing...
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