Genetic clues to understanding periodic fevers, and possible therapies.

Abstract excerpt

Significant breakthroughs in our understanding of the molecular basis of the inflammatory response have been achieved in the past five years, with the successive identification of the genetic basis of all known hereditary periodic-fever syndromes. Impaired cytokine recognition and defective signalling molecules have been implicated in the inception of recurrent attacks of fever with acute-phase protein response....

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