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Article

Transfer, analysis, and reversion of the fibrous dysplasia cellular phenotype in human skeletal progenitors.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 May 2010

Piersanti Stefania, Remoli Cristina, Saggio Isabella, Funari Alessia, Michienzi Stefano, Sacchetti Benedetto, Robey Pamela Gehron, Riminucci Mara, Bianco Paolo

Abstract excerpt

Human skeletal progenitors were engineered to stably express R201C mutated, constitutively active Gs alpha using lentiviral vectors. Long-term transduced skeletal progenitors were characterized by an enhanced production of cAMP, indicating the transfer of the fundamental cellular phenotype caused by activating mutations of Gs alpha. Like skeletal progenitors isolated from natural fibrous dysplasia (FD) lesions,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19874199
DOI: 10.1359/jbmr.091036
PMCID: PMC5524372

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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