Article
Evolution of a genetic disease in an ethnic isolate: beta-thalassemia in the Jews of Kurdistan.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jan 1991
Rund D, Cohen T, Filon D, Dowling C E, Warren T C, Barak I, Rachmilewitz E, Kazazian H H, Oppenheim A
Abstract excerpt
beta-Thalassemia is a hereditary disease caused by any of 90 different point mutations in the beta-globin gene. Specific populations generally carry a small number of mutations, the most common of which are those that are widely distributed regionally. The present study constitutes an extensive molecular characterization of this disease in a small, highly inbred ethnic group with a high incidence of...
Topics
- Base Sequence
- Female
- Genes
- Globins
- Humans
- Iran
- Iraq
- Israel
- Jews
- Male
- Molecular Sequence Data
- Mutation