Low-risk variants FGFR2, TNRC9 and LSP1 in German familial breast cancer patients.

doi:10.1002/ijc.24986

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Article

Low-risk variants FGFR2, TNRC9 and LSP1 in German familial breast cancer patients.

International journal of cancer - 15 Jun 2010

Hemminki Kari, Müller-Myhsok Bertram, Lichtner Peter, Engel Christoph, Chen Bowang, Burwinkel Barbara, Försti Asta, Sutter Christian, Wappenschmidt Barbara, Hellebrand Heide, Illig Thomas, Arnold Norbert, Niederacher Dieter, Dworniczak Bernd, Deissler Helmut, Kast Karin, Gadzicki Dorothea, Meitinger Thomas, Wichmann H-Erich, Kiechle Marion, Bartram Claus R, Schmutzler Rita K, Meindl Alfons

Abstract excerpt

To validate common low-risk variants predisposing for breast cancer (BC) in a large set of BRCA1/2 negative familial or genetically enriched cases from Germany, we genotyped 1,415 cases and 1,830 healthy women by MALDI-TOF in 105 candidate SNPs. Significantly higher ORs than previously reported for heterozygous unselected cases were found for the minor allele in FGFR2 (OR = 1.43, 95% CI 1.30-1.59, p-value = 1.24...

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Identifiers

PMID: 19856316
DOI: 10.1002/ijc.24986

Genes

FGFR2
LSP1
BRCA1

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