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Article

Genetic variants in FGFR2 and MAP3K1 are associated with the risk of familial and early-onset breast cancer in a South-American population.

Breast cancer research and treatment - 1 Jan 2013

Jara Lilian, Gonzalez-Hormazabal Patricio, Cerceño Kerube, Di Capua Gabriella A, Reyes Jose M, Blanco Rafael, Bravo Teresa, Peralta Octavio, Gomez Fernando, Waugh Enrique, Margarit Sonia, Ibañez Gladys, Romero Carmen, Pakomio Janara, Roizen Gigia

Abstract excerpt

Genome-Wide Association Studies have identified several loci associated with breast cancer (BC) in populations of different ethnic origins. One of the strongest associations was found in the FGFR2 gene, and MAP3K1 has been proposed as a low-penetrance BC risk factor. In this study, we evaluated the associations among FGFR2 SNPs rs2981582, rs2420946, and rs1219648; and MAP3K1 rs889312, with BC risk in 351...

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Source

Identifiers

PMID: 23225170
DOI: 10.1007/s10549-012-2359-z

Genes

FGFR2
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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