Article
Fibroblast growth factor receptor 3 mutation in voided urine is a useful diagnostic marker and significant indicator of tumor recurrence in non-muscle invasive bladder cancer.
Cancer science - 1 Jan 2010
Miyake Makito, Sugano Kokichi, Sugino Hitomi, Imai Kazuho, Matsumoto Eri, Maeda Koshi, Fukuzono Shinich, Ichikawa Hiroki, Kawashima Kiyotaka, Hirabayashi Kaoru, Kodama Tetsuro, Fujimoto Hiroyuki, Kakizoe Tadao, Kanai Yae, Fujimoto Kiyohide, Hirao Yoshihiko
Abstract excerpt
The fibroblast growth factor receptor (FGFR)-3 gene encodes a receptor tyrosine kinase that is frequently mutated in non-muscle invasive bladder cancer (NMIBC). A sensitive and quantitative assay using peptide nucleic acid-mediated real-time PCR was developed for detecting FGFR3 mutations in the urine samples and evaluated as a molecular marker for detecting intravesical recurrence of NMIBC in patients undergoing...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.