Article
[Detection of single nucleotide polymorphisms of Jak2 gene in multiple myeloma by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry].
Zhongguo shi yan xue ye xue za zhi - 1 Oct 2009
Zhoang Yue-Jiao, Chen Bao-An, Cheng Lu, Feng Ji-Feng, Li Yu-Feng, Qian Jun, Ding Jia-Hua, Cheng Jian, Gao Feng, Xia Guo-Hua, Sun Ning, Zhang Yan, Zhang Xiao-Ping, Xu Pei-Pei, Lu Zu-Hong
Abstract excerpt
This study was purposed to investigate the practicality of matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS) for detection of single nucleotide polymorphisms (SNP) on jak2 gene in multiple myeloma (MM) cells. The DNA fragment containing 2 SNPs of jak2 (C428T and C643T) was amplified using PCR and was purified. The purified product was used as the template for primer...
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