Article
HDAC inhibitor trichostatin A-inhibited survival of dopaminergic neuronal cells.
Neuroscience letters - 31 Dec 2009
Wang Yong, Wang Xuan, Liu Limin, Wang Xiaomin
Abstract excerpt
Histone deacetylase (HDAC) inhibitors have been shown associated with neurodegenerative diseases. However, their effects on survival of dopaminergic neurons remain uncertain. In the present study, the HDAC inhibitor trichostatin A (TSA) was tested in following dopaminergic neuronal cell lines: rat N27, mouse MN9D, and human SH-SY5Y cells. Results demonstrated that a single TSA treatment resulted in decreased cell...
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