Article
The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer.
BMC gastroenterology - 16 Oct 2009
Guan Xiaoxiang, Zhao Hui, Niu Jiangong, Tang Dongfeng, Ajani Jaffer A, Wei Qingyi
Abstract excerpt
BACKGROUND: Both TGF-beta1 and VEGF play a critic role in the multiple-step process of tumorgenesis of gastric cancer. Single nucleotide polymorphisms (SNPs) of the TGFB1 and VEGF genes have been associated with risk and progression of many cancers. In this study, we investigated the association between potentially functional SNPs of these two genes and risk of gastric cancer in a US population. METHODS: The risk...
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