Article
Selecting for BRCA1 testing using a combination of homogeneous selection criteria and immunohistochemical characteristics of breast cancers.
BMC cancer - 10 Oct 2009
Miolo GianMaria, Canzonieri Vincenzo, De Giacomi Clelia, Puppa Lara Della, Dolcetti Riccardo, Lombardi Davide, Perin Tiziana, Scalone Simona, Veronesi Andrea, Viel Alessandra
Abstract excerpt
BACKGROUND: BRCA1 gene-related tumours are more frequently estrogen receptor (ER) and progesterone receptor (PR) negative with a lower prevalence of human epidermal growth factor receptor 2 (HER2) overexpression or amplification. We evaluated the effectiveness of a combination of homogeneously selected criteria and immunohistochemical (IHC) characteristics of Familial Breast Cancers (FBCs) in detecting BRCA1...
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