Article
Balancing needs and means: the dilemma of the beta-cell in the modern world.
Diabetes, obesity & metabolism - 1 Nov 2009
Leibowitz G, Kaiser N, Cerasi E
Abstract excerpt
The insulin resistance of type 2 diabetes mellitus (T2DM), although important for its pathophysiology, is not sufficient to establish the disease unless major deficiency of beta-cell function coexists. This is demonstrated by the fact that near-physiological administration of insulin (CSII) achieved excellent blood glucose control with doses similar to those used in insulin-deficient type 1 diabetics. The normal...
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