Article
Influence of aggregation propensity and stability on amyloid fibril formation as studied by Fourier transform infrared spectroscopy and two-dimensional COS analysis.
Biochemistry - 10 Nov 2009
Cerdà-Costa Núria, De la Arada Igor, Avilés Francesc X, Arrondo José L R, Villegas Sandra
Abstract excerpt
Understanding the process of amyloidogenesis is important for the future treatment of misfolding-based diseases, such as Alzheimer's, spongiform encephalopathies, and other important disorders affecting humans. In this work, we have used one of the best-characterized models for folding and misfolding, the activation domain of human procarboxypeptidase A2 (ADA2h). The wild type (WT) and three mutants affecting the...
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