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Article

Polymorphisms in CYP1B1 modify the risk of idiopathic male infertility with abnormal semen quality.

Clinica chimica acta; international journal of clinical chemistry - 18 Sept 2011

Hu Weiyue, Yang Hua, Sun Jie, Zhang Qiuyi, Yang Jingjin, Lu Lu, Zhang Jiacheng, Qin Yufeng, Xia Yankai, Wang Xinru

Abstract excerpt

BACKGROUND: It is acknowledged that Cytochrome P450 1B1 (CYP1B1) plays a crucial role in metabolism and is involved in lots of diseases. We carried out this study to evaluate the association between CYP1B1 single nucleotide polymorphisms (SNPs) and male infertility in the Han-Chinese population with abnormal semen parameters. METHODS: We genotyped five CYP1B1 polymorphisms by using TaqMan allelic discrimination...

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PMID: 21683070
DOI: 10.1016/j.cca.2011.05.037

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