Article
Further evidence for an association between mandibular height and the growth hormone receptor gene in a Japanese population.
American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics - 1 Oct 2009
Tomoyasu Yoko, Yamaguchi Tetsutaro, Tajima Atsushi, Nakajima Toshiaki, Inoue Ituro, Maki Koutaro
Abstract excerpt
INTRODUCTION: Craniofacial morphology has a significant genetic component. It has recently been reported that single nucleotide polymorphisms (SNPs) in the growth hormone receptor gene (GHR) are associated with mandibular height. To confirm these findings, we genotyped SNPs in healthy Japanese subjects, about 1.7 times the number analyzed in previous reports. METHODS: By using 5 SNPs in exon 10 of the GHR, we...
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