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Article

The amidase domain of lipoamidase specifically inactivates lipoylated proteins in vivo.

PloS one - 8 Oct 2009

Spalding Maroya D, Prigge Sean T

Abstract excerpt

BACKGROUND: In the 1950s, Reed and coworkers discovered an enzyme activity in Streptococcus faecalis (Enterococcus faecalis) extracts that inactivated the Escherichia. coli and E. faecalis pyruvate dehydrogenase complexes through cleavage of the lipoamide bond. The enzyme that caused this lipoamidase activity remained unidentified until Jiang and Cronan discovered the gene encoding lipoamidase (Lpa) through the...

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Identifiers

PMID: 19812687
DOI: 10.1371/journal.pone.0007392
PMCID: PMC2753649

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