Article
Independent contribution of common CFTR variants to chronic pancreatitis.
Pancreas - 1 Mar 2010
de Cid Rafael, Ramos Maria D, Aparisi Luís, García Cecilia, Mora Josefina, Estivill Xavier, Farré Antoni, Casals Teresa
Abstract excerpt
OBJECTIVE: We have assessed whether CFTR gene has a major impact on chronic pancreatitis (CP) pathogenesis than that provided by the CFTR mutations. For this aim, we have evaluated clinical parameters, CFTR mutations, and 3 potential regulatory CFTR variants (coding single-nucleotide polymorphisms): c.1540A>G, c.2694T>G, and c.4521G>A. METHODS: CFTR gene analysis was performed in a cohort of 136 CP patients and...
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