Completion of the intron-exon structure of the gene for human type II procollagen (COL2A1): variations in the nucleotide sequences of the alleles from three chromosomes.

Abstract excerpt

A new procedure for preparing cosmid libraries was used to isolate three alleles for the human gene for type II procollagen (COL2A1). Over 20,000 bp of one allele were completely sequenced and over 10,000 bp of the two other alleles were sequenced. The data located and defined 26 exons and introns of the gene not previously analyzed. The results completed the structure of the gene except for the newly discovered...

Topics

• Alleles
• Base Sequence
• Collagen Diseases
• Cosmids
• Exons
• Genes
• Humans
• Introns
• Molecular Sequence Data
• Osteoarthritis
• Polymorphism, Restriction Fragment Length