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Article

Clindamycin-induced CovS-mediated regulation of the production of virulent exoproteins streptolysin O, NAD glycohydrolase, and streptokinase in Streptococcus pyogenes.

Antimicrobial agents and chemotherapy - 1 Jan 2010

Minami Masaaki, Kamimura Takuya, Isaka Masanori, Tatsuno Ichiro, Ohta Michio, Hasegawa Tadao

Abstract excerpt

The administration of high-dose clindamycin (CLI) along with penicillin is recommended for the treatment of streptococcal toxic shock syndrome. However, the prevalence of CLI-resistant Streptococcus pyogenes strains is increasing worldwide, and the effect of CLI on CLI-resistant S. pyogenes strains remains unknown. We aimed to evaluate the effect of CLI on the in vitro production of three major virulent...

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Identifiers

PMID: 19805566
DOI: 10.1128/AAC.00804-09
PMCID: PMC2798487

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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