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Article

Highly frequent mutations in negative regulators of multiple virulence genes in group A streptococcal toxic shock syndrome isolates.

PLoS pathogens - 1 Apr 2010

Ikebe Tadayoshi, Ato Manabu, Matsumura Takayuki, Hasegawa Hideki, Sata Tetsutaro, Kobayashi Kazuo, Watanabe Haruo

Abstract excerpt

Streptococcal toxic shock syndrome (STSS) is a severe invasive infection characterized by the sudden onset of shock and multiorgan failure; it has a high mortality rate. Although a number of studies have attempted to determine the crucial factors behind the onset of STSS, the responsible genes in group A Streptococcus have not been clarified. We previously reported that mutations of csrS/csrR genes, a...

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Identifiers

PMID: 20368967
DOI: 10.1371/journal.ppat.1000832
PMCID: PMC2848555

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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