Article
BG1 has a major role in MHC-linked resistance to malignant lymphoma in the chicken.
Proceedings of the National Academy of Sciences of the United States of America - 29 Sept 2009
Goto Ronald M, Wang Yujun, Taylor Robert L, Wakenell Patricia S, Hosomichi Kazuyoshi, Shiina Takashi, Blackmore Craig S, Briles W Elwood, Miller Marcia M
Abstract excerpt
Pathogen selection is postulated to drive MHC allelic diversity at loci for antigen presentation. However, readily apparent MHC infectious disease associations are rare in most species. The strong link between MHC-B haplotype and the occurrence of virally induced tumors in the chicken provides a means for defining the relationship between pathogen selection and MHC polymorphism. Here, we verified a significant...
Topics
- Alleles
- Animals
- Chickens
- Haplotypes
- Immunity, Innate
- Lymphoma
- Major Histocompatibility Complex
- Marek Disease
- Molecular Sequence Data
- Poultry Diseases
- Protein Tyrosine Phosphatases