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Article

Influence of genetic variation in CYP3A4 and ABCB1 on dose decrease or switching during simvastatin and atorvastatin therapy.

Pharmacoepidemiology and drug safety - 1 Jan 2010

Becker Matthijs L, Visser Loes E, van Schaik Ron H N, Hofman Albert, Uitterlinden André G, Stricker Bruno H Ch

Abstract excerpt

PURPOSE: Simvastatin and atorvastatin are metabolized by the CYP3A4 enzyme and transported by the ABCB1 transporter. We studied whether the polymorphism CYP3A4*1B and the polymorphisms C1236T, G2677A/T and C3435T in the ABCB1 gene were associated with a decrease of the prescribed dose or a switch to another cholesterol lowering drug during simvastatin and atorvastatin therapy. These events may indicate that...

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Source

Identifiers

PMID: 19802823
DOI: 10.1002/pds.1866

Genes

ABCB1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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