Article
Transcriptional regulation of Tlr11 gene expression in epithelial cells.
The Journal of biological chemistry - 27 Nov 2009
Cai Zhenyu, Shi Zhongcheng, Sanchez Amir, Zhang Tingting, Liu Mingyao, Yang Jianghua, Wang Fen, Zhang Dekai
Abstract excerpt
As sensors of invading microorganisms, Toll-like receptors (TLRs) are expressed not only on macrophages and dendritic cells (DCs) but also on epithelial cells. In the TLR family, Tlr11 appears to have the unique feature in that it is expressed primarily on epithelial cells, although it is also expressed on DCs and macrophages. Here, we demonstrate that transcription of the Tlr11 gene is regulated through two...
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