Article
Circling behavior exhibited by a transgenic insertional mutant.
Brain research. Molecular brain research - 1 Oct 1990
Ratty A K, Fitzgerald L W, Titeler M, Glick S D, Mullins J J, Gross K W
Abstract excerpt
We report here of an abnormal circling behavior expressed in the TgX15 transgenic mouse line as a result of insertional mutagenesis. Homozygous transgenic mice expressed the phenotype while heterozygous transgenics were normal. We also found that the dopamine D2 receptor binding sites in the striata of the circling mice were significantly elevated by about 31% compared to normal heterozygous transgenic mice....
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