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Article

Synergistic effect between proteasome and autophagosome in the clearance of polyubiquitinated TDP-43.

Journal of neuroscience research - 1 Mar 2010

Urushitani Makoto, Sato Takashi, Bamba Hitoshi, Hisa Yasuo, Tooyama Ikuo

Abstract excerpt

Cytoplasmic aggregates of ubiquitinated TAR DNA-binding protein 43 (TDP-43) are a pathological hallmark of amyotrophic lateral sclerosis (ALS). However, the mechanism of TDP-43 polyubiquitination remains elusive. We investigated the effect of nuclear exclusion of TDP-43 on aggregate formation and...

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PMID: 19798749
DOI: 10.1002/jnr.22243

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19798749-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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