beta-TrCP-mediated ubiquitination and degradation of PHLPP1 are negatively regulated by Akt.

Abstract excerpt

PHLPP1 belongs to a novel family of Ser/Thr protein phosphatases that serve as tumor suppressors by negatively regulating Akt signaling. Our recent studies have demonstrated that loss of PHLPP expression occurs at high frequency in colorectal cancer. In this study, we identified PHLPP1 as a proteolytic target of a beta-TrCP-containing Skp-Cullin 1-F-box protein (SCF) complex (SCF(beta-TrCP)) E3 ubiquitin ligase...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Casein Kinase I
• Share to Down-Regulation
• Share to Glycogen Synthase Kinase 3