Article
Recombinogenic activity of fluoxetine in Aspergillus nidulans.
Drug and chemical toxicology - 1 Jan 2009
de Castro-Prado Juliana, Franco Claudinéia C da Silva, de Sant'Anna Juliane R, Miyamoto Claudia T, de Castro-Prado Marialba A A
Abstract excerpt
The recombinogenic potential of fluoxetine, an antidepressant widely prescribed in the treatment of depressive disorders in cancer patients, was investigated in this study. A heterozygous diploid strain of Aspergillus nidulans was utilized. Fluoxetine at 7.5, 15, and 30 microM concentrations induced homozygosity of several nutritional genetic markers and significantly increased their homozygotization index...
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