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Article

Splenectomy normalizes hematocrit in murine polycythemia vera.

PloS one - 30 Sept 2009

Mo Jan-Rung, Mathur Anjili, Angagaw Minilik, Zhao Shuxia, Wang Yuxun, Gargano Diana, DiBacco Alessandra, Bachman Eric S

Abstract excerpt

Splenic enlargement (splenomegaly) develops in numerous disease states, although a specific pathogenic role for the spleen has rarely been described. In polycythemia vera (PV), an activating mutation in Janus kinase 2 (JAK2(V617)) induces splenomegaly and an increase in hematocrit. Splenectomy is sparingly performed in patients with PV, however, due to surgical complications. Thus, the role of the spleen in the...

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Identifiers

PMID: 19789710
DOI: 10.1371/journal.pone.0007286
PMCID: PMC2749451

Genes

JAK2

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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