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Article

Splenectomy normalizes hematocrit in murine polycythemia vera.

PloS one - 30 Sept 2009

Mo Jan-Rung, Mathur Anjili, Angagaw Minilik, Zhao Shuxia, Wang Yuxun, Gargano Diana, DiBacco Alessandra, Bachman Eric S

Abstract excerpt

Splenic enlargement (splenomegaly) develops in numerous disease states, although a specific pathogenic role for the spleen has rarely been described. In polycythemia vera (PV), an activating mutation in Janus kinase 2 (JAK2(V617)) induces splenomegaly and an increase in hematocrit. Splenectomy is...

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Identifiers

PMID: 19789710
DOI: 10.1371/journal.pone.0007286
PMCID: PMC2749451

Genes

JAK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19789710-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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