Article
Sendai virus-mediated CFTR gene transfer to the airway epithelium.
Gene therapy - 1 Oct 2007
Ferrari S, Griesenbach U, Iida A, Farley R, Wright A M, Zhu J, Munkonge F M, Smith S N, You J, Ban H, Inoue M, Chan M, Singh C, Verdon B, Argent B E, Wainwright B, Jeffery P K, Geddes D M, Porteous D J, Hyde S C, Gray M A, Hasegawa M, Alton E W F W
Abstract excerpt
The potential for gene therapy to be an effective treatment for cystic fibrosis has been hampered by the limited gene transfer efficiency of current vectors. We have shown that recombinant Sendai virus (SeV) is highly efficient in mediating gene transfer to differentiated airway epithelial cells, because of its capacity to overcome the intra- and extracellular barriers known to limit gene delivery. Here, we have...
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