Article
Towards targeted epigenetic therapy of cancer.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology - 1 Sept 2009
Magic Z, Supic G, Brankovic-Magic M
Abstract excerpt
Increasing number of publications in the last 10 years implicated that cancer development depends, except genetic alterations, also on inheritable gene expression patterns that are not bound to DNA sequence alterations. These epigenetic mechanisms manifest mostly through changes in chromatin packing and in localized gene promoter changes that influence the transcription of the genes involved in carcinogenesis....
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