Article
Prediction of nonSVR to therapy with pegylated interferon-alpha2a and ribavirin in chronic hepatitis C genotype 1 patients after 4, 8 and 12 weeks of treatment.
Journal of viral hepatitis - 1 May 2010
Lukasiewicz E, Gorfine M, Freedman L S, Pawlotsky J-M, Schalm S W, Ferrari C, Zeuzem S, Neumann A U
Abstract excerpt
In patients with chronic hepatitis C genotype 1, the current algorithm for treatment discontinuation is based on no early virological response (<2 log decline in hepatitis C virus (HCV)-RNA) at 12 weeks. It is important to determine whether prediction of nonsustained virological response (NR) before 12 weeks can be robustly obtained by statistical methods. We used longitudinal discriminant analysis (LDA) to build...
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