Article
Selective inhibition of type III secretion activated signaling by the Salmonella effector AvrA.
PLoS pathogens - 1 Sept 2009
Du Fangyong, Galán Jorge E
Abstract excerpt
Salmonella enterica utilizes a type III secretion system (TTSS) encoded in its pathogenicity island 1 to mediate its initial interactions with intestinal epithelial cells, which are characterized by the stimulation of actin cytoskeleton reorganization and a profound reprogramming of gene expression. These responses result from the stimulation of Rho-family GTPases and downstream signaling pathways by specific...
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