Article
Clinical outcomes of advanced non-small cell lung cancer patients screened for epidermal growth factor receptor gene mutations.
Journal of cancer research and clinical oncology - 1 Apr 2010
Yoshida Kimihide, Yatabe Yasushi, Park Jangchul, Ogawa Shizu, Park Ji Young, Shimizu Junichi, Horio Yoshitsugu, Matsuo Keitaro, Mitsudomi Tetsuya, Hida Toyoaki
Abstract excerpt
PURPOSE: To evaluate the relationship between the epidermal growth factor receptor (EGFR) mutation status and the effectiveness of gefitinib monotherapy or chemotherapy in patients with advanced non-small cell lung cancer (NSCLC). METHODS: We retrospectively analyzed a cohort of 100 patients with stage IIIB/IV NSCLC screened for two major EGFR mutations (exon 19 deletions and L858R mutation). RESULTS: Forty-six...
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