Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Post-translational modifications of connexin26 revealed by mass spectrometry.

The Biochemical journal - 10 Dec 2009

Locke Darren, Bian Shengjie, Li Hong, Harris Andrew L

Abstract excerpt

Gap junctions play important roles in auditory function and skin biology; mutations in the Cx26 (connexin26) gene are the predominant cause of inherited non-syndromic deafness and cause disfiguring skin disorders. Mass spectrometry (MS) was used to identify PTMs (post-translational modifications) of Cx26 and to determine whether they occur at sites of disease-causing mutations. Cx26 was isolated from transfected...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chymotrypsin
Share to Connexin 26
Share to Deafness

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endopeptidases

Share to Hydroxylation

Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Share to Tandem Mass Spectrometry

Share to Trypsin

Source

Open in PubMed Open full text

Identifiers

PMID: 19775242
DOI: 10.1042/BJ20091140
PMCID: PMC4640697

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Post-translational modifications of connexin26 revealed by mass spectrometry.PMID 19775242Read ↗

Degradation and modification of cochlear gap junction proteins in the early development of age-related hearing loss.Semantic proximity Read ↗

A novel N14Y mutation in Connexin26 in keratitis-ichthyosis-deafness syndrome: analyses of altered gap junctional communication and molecular structure of N terminus of mutated Connexin26.Semantic proximity Read ↗

Assembly of the cochlear gap junction macromolecular complex requires connexin 26.Semantic proximity Read ↗

Connexins: Synthesis, Post-Translational Modifications and Trafficking in Health and DiseaseSemantic proximity Read ↗

The p.Cys169Tyr variant of connexin 26 is not a polymorphism.Semantic proximity Read ↗

Cellular mechanisms of mutant connexins in skin disease and hearing loss.Semantic proximity Read ↗

Connexin26 Mutations Causing Palmoplantar Keratoderma and Deafness Interact with Connexin43, Modifying Gap Junction and Hemichannel Properties.Semantic proximity Read ↗

Analysis of trafficking, stability and function of human connexin 26 gap junction channels with deafness-causing mutations in the fourth transmembrane helix.Semantic proximity Read ↗

Functional consequences of novel connexin 26 mutations associated with hereditary hearing loss.Semantic proximity Read ↗

Connexin 26 (GJB2) mutations, causing KID Syndrome, are associated with cell death due to calcium gating deregulation.Semantic proximity Read ↗

Three-dimensional structure of a human connexin26 gap junction channel reveals a plug in the vestibule.Semantic proximity Read ↗

Mutation R184Q of connexin 26 in hearing loss patients has a dominant-negative effect on connexin 26 and connexin 30.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.