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Functional analysis of polyomavirus BK non‐coding control region quasispecies from kidney transplant recipients

22 Sept 2009

Abstract excerpt

Replication of the human polyomavirus BK (BKV) in renal tubular epithelial cells causes viruria and BKV-nephropathy in kidney transplant recipients. Following prolonged high-level BKV replication, rearrangement of the archetype non-coding control region (NCCR) leads to a mixture of BKV variants. The aim of this study was to compare potential functional differences of 12 rearranged (rr)-NCCR variants with the...

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PMID: 19774689
DOI: 10.1002/jmv.21605

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