Article
Polymorphisms in telomere maintenance genes and risk of lung cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Oct 2009
Choi Jin Eun, Kang Hyo-Gyoung, Jang Jin Sung, Choi Yi Young, Kim Min Jung, Kim Jong Sik, Jeon Hyo-Sung, Lee Won Kee, Cha Sung Ick, Kim Chang Ho, Kam Sin, Jung Tae Hoon, Park Jae Yong
Abstract excerpt
This study was conducted to comprehensively evaluate the associations between polymorphisms in telomere maintenance genes (TERT, TRF1, TNKS1, TRF2, RAP1, and POT1) and lung cancer risk. We captured 35 polymorphisms in the genes and determined their frequencies in 27 healthy Koreans. Ten haplotype-tagging polymorphisms were examined in a case-control study that consisted of 720 lung cancer patients and 720 healthy...
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