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Article

Effect of raltegravir resistance mutations in HIV-1 integrase on viral fitness.

Journal of acquired immune deficiency syndromes (1999) - 1 Oct 2010

Hu Zixin, Kuritzkes Daniel R

Abstract excerpt

Raltegravir resistance is conferred by mutations at integrase codons 143, 148, and 155 together with associated secondary mutations. The N155H mutants emerge first, and are eventually replaced by Q148H mutants, usually in combination with G140S. These mutations have different effects on susceptibility and replication capacity, but data on the relative fitness of RAL-resistant viruses are limited. To understand...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20634701
DOI: 10.1097/QAI.0b013e3181e9a87a
PMCID: PMC2943977

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