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Article

ADAM12 localizes with c-Src to actin-rich structures at the cell periphery and regulates Src kinase activity.

Experimental cell research - 1 Jan 2010

Stautz Dorte, Sanjay Archana, Hansen Matilde Thye, Albrechtsen Reidar, Wewer Ulla M, Kveiborg Marie

Abstract excerpt

ADAM12 is an active metalloprotease playing an important role in tumour progression. Human ADAM12 exists in two splice variants: a long transmembrane form, ADAM12-L, and a secreted form, ADAM12-S. The subcellular localization of ADAM12-L is tightly regulated and involves intracellular interaction partners and signalling proteins. We demonstrate here a c-Src-dependent redistribution of ADAM12-L from perinuclear...

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Source

Identifiers

PMID: 19769962
DOI: 10.1016/j.yexcr.2009.09.017

Genes

ADAM12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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